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pentobarbital decreases levels of toremifene by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers increase charge of toremifene metabolism, lowering the regular-condition focus in serum.pentobarbital will minimize the level or effect of dasatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use